期刊
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 5, 期 10, 页码 9517-9526出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.7b02727
关键词
Ionic liquid microemulsion; Cross-linking; Starch nanoparticle; OSA modification; OSA modification; Drug loading and release
资金
- National Natural Science Foundation of China [21576098, 21376097]
- Key Project of Science and Technology of Guangdong Province [2016A050502005, 2015A020209015, 2017B090901002]
- Key Project of Science and Technology of Guangzhou City [201508020082]
- China Postdoctoral Science Foundation [2016M590787, 2017T100616]
In this work, an enhanced starch-dissolving room-temperature ionic liquid 1-hydroxypropyl-3-methylimidazolium acetate ([C(3)OHmim]Ac) was tailor-made to serve as the polar phase in the formation of [C(3)OHmim]Ac/TX-100 + 1-butanol/cyclohexane (IL/O) microemulsion. Its superior solubility to starch was verified by the polarized-light microscope and turbidity test. Furthermore, a pseudoternary phase diagram, conductivity measurement, and dynamic light scattering (DLS) were used to analyze the phase behavior and microregion of IL/O microemulsion. On this basis starch nanoparticles with a mean diameter of 86.69 nm were successfully prepared in this novel IL/O microemulsion with octenyl succinic anhydride (OSA) maize starch as the raw material and epichlorohydrin as a cross-linker through microemulsion cross-linking reaction. For starch nanoparticles, Fourier transform infrared spectroscopy (FTIR) data demonstrated the formation of ester bonds, and cross-linking reaction in starch molecules and X-ray diffraction (XRD) disclosed the destruction of the crystal structure. In addition, scanning electron microscopy (SEM) intuitively revealed that OSA modified starch nanoparticles possessed good dispersibility, nanoscaled size, and a relatively concentrated size distribution. Finally, drug loading and releasing properties of starch nanoparticles were investigated with indomethacin as a drug model.
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