期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 312, 期 1, 页码 R1-R4出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.00414.2016
关键词
hypertension; inflammation; salt
类别
资金
- American Heart Association's Strategically Focused Research Network Grant [14SFRN20420046]
- National Institutes of Health [R01HL-039006, P01HL-058000, P01HL-095070, P01GM-015431, R01HL108701, R01HL-105294, K01HL-130497]
Hypertension is a global epidemic affecting over one billion people worldwide. Despite this, the etiology of most cases of human hypertension remains obscure, and treatment remains suboptimal. Excessive dietary salt and inflammation are known contributors to the pathogenesis of this disease. Recently, it has been recognized that salt can accumulate in the skin and skeletal muscle, producing concentrations of sodium greater than the plasma in hypertensive animals and humans. Such elevated levels of sodium have been shown to alter immune cell function. Here, we propose a model in which tissue salt accumulation causes an immune response leading to renal and vascular inflammation and hypertension.
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