期刊
DEVELOPMENT GROWTH & DIFFERENTIATION
卷 59, 期 1, 页码 4-11出版社
WILEY-BLACKWELL
DOI: 10.1111/dgd.12336
关键词
extracellular matrix; size control; tubulogenesis; viscoelasticity
资金
- MEXT, Japan [22111007, 15H01501]
- RIKEN Foreign Postdoctoral Researcher Program
- Taishan Scholar Program of Shandong Province in China
- Grants-in-Aid for Scientific Research [15H01501, 22111007] Funding Source: KAKEN
For efficient respiration, tubular airways must be constructed with an optimal diameter and length for the dimensions of the body. In Drosophila, the growth of embryonic tracheal tubules proceeds in two dimensions, by axial elongation and diameter expansion. The growth forces in each dimension are controlled by distinct genetic programs and cellular mechanisms. Recent studies reveal that the apical cortex and the apical extracellular matrix filling the luminal space are essential for the generation, balancing, and equilibrium of these growth forces. We here discuss the mechanical properties and architecture of the apical cortex and extracellular matrix, and their crucial roles in the tissue-level coordination of tubule shape and geometry.
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