期刊
CURRENT ALLERGY AND ASTHMA REPORTS
卷 17, 期 1, 页码 -出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11882-017-0675-4
关键词
Atopic dermatitis; Epicutaneous allergy; Detergent; Cutaneous sensitization; Skin
资金
- UVA Child Health Research Grant
Purpose of Review This second part of the article aims to highlight recent contributions in the literature that enhance our understanding of the cutaneous immune response to allergen. Recent Findings Several properties of allergens facilitate barrier disruption and cutaneous sensitization. There is a strong epidemiologic relationship between the microbiome, both the gut and skin, and atopic dermatitis (AD). The mechanisms connecting these two entities remain enigmatic; however, recent murine models show that commensal skin bacteria play an active role in supporting skin barrier homeostasis and defense against microbial penetration. Likewise, the association between the lack of colonization with Staph species and AD development suggests a potentially functional role for these organisms in regulating the skin barrier and response to environmental allergens. In undisrupted skin, evidence suggests that the cutaneous route may promote allergen tolerance. Summary Properties of environmental allergens and commensal bacteria add to the complex landscape of skin immunity. Further investigation is needed to elucidate how these properties regulate the cutaneous immune response to allergen.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据