期刊
COMPREHENSIVE PHYSIOLOGY
卷 7, 期 1, 页码 235-252出版社
WILEY
DOI: 10.1002/cphy.c160007
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资金
- Biotechnology and Biological Research Council [BB/J004723/1]
- Medical Research Council [MR/M022838/1]
- NIH [DA033811, DA038616, AG049137]
- Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders
- Biotechnology and Biological Sciences Research Council [BB/J004723/1] Funding Source: researchfish
- Medical Research Council [MR/M022838/1] Funding Source: researchfish
Release of neuroactive substances by exocytosis from dendrites is surprisingly widespread and is not confined to a particular class of transmitters: it occurs in multiple brain regions, and includes a range of neuropeptides, classical neurotransmitters, and signaling molecules, such as nitric oxide, carbon monoxide, ATP, and arachidonic acid. This review is focused on hypothalamic neuroendocrine cells that release vasopressin and oxytocin and midbrain neurons that release dopamine. For these two model systems, the stimuli, mechanisms, and physiological functions of dendritic release have been explored in greater detail than is yet available for other neurons and neuroactive substances. (C) 2017 American Physiological Society.
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