期刊
WILEY INTERDISCIPLINARY REVIEWS-RNA
卷 8, 期 6, 页码 -出版社
WILEY
DOI: 10.1002/wrna.1437
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资金
- Faculte de Medecine et des Sciences de la Sante de l'Universite de Sherbrooke
- Natural Sciences and Engineering Research Council of Canada [RGPIN-2016-03916]
- National Institutes of Health [5 R01 AI114675]
Flaviviruses, such as dengue, Japanese encephalitis, West Nile, yellow fever, and Zika viruses, are serious human pathogens that cause significant morbidity and mortality globally each year. Flaviviruses are single-stranded, positive-sense RNA viruses, and encode two multidomain proteins, NS3 and NS5, that possess all enzymatic activities required for genome replication and capping. NS3 and NS5 interact within virus-induced replication compartments to form the RNA genome replicase complex. Although the individual enzymatic activities of both proteins have been extensively studied and are well characterized, there are still gaps in our understanding of how they interact to efficiently coordinate their respective activities during positive-strand RNA synthesis and capping. Here, we discuss what is known about the structures and functions of the NS3 and NS5 proteins and propose a preliminary NS3:NS5:RNA interaction model based on a large body of literature about how the viral enzymes function, physical restraints between NS3 and NS5, as well as critical steps in the replication process. (C) 2017 Wiley Periodicals, Inc.
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