期刊
CANCER LETTERS
卷 387, 期 -, 页码 69-76出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.04.018
关键词
Treatment resistance; Cancer stem cells; Cancer progression; Mutation; EMT; EMT transition
类别
资金
- National Health and Medical Research Council of Australia (NHMRC) Program [APP1053206]
- NHMRC [APP1047417, APP1087297]
- Cancer Council NSW Project [APP1070076, APP1069733]
Chemotherapy is the standard treatment for many, if not all, metastatic cancers. While chemotherapy is often capable of inducing cell death in tumors leading to shrinkage of the tumor bulk, many patients suffer from recurrence and ultimately death due to resistance. During the last decade, treatment resistance has attracted great attention followed by some seminal discoveries, including sequential mutations, cancer stem cells, and bidirectional inter-conversion of stem and non-stem cancer cell populations. Nevertheless, the successful treatment of cancer will require a considerable refinement of our knowledge concerning treatment resistance. In doing so, we expect that a more informed and refined approach to treat cancer will be developed and this may improve prognosis of cancer patients. In this review, we will discuss the current knowledge concerning the failure of cancer treatments and the potential approaches to overcome therapeutic resistance. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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