期刊
CANCER LETTERS
卷 387, 期 -, 页码 46-60出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2016.06.004
关键词
Innate immune signaling; PRRs; Cancer; Cardiometabolic diseases
类别
资金
- National Science Fund for Distinguished Young Scholars [81425005]
- Key Project of the National Natural Science Foundation [81330005]
- National Natural Science Foundation of China [81370209, 81370365, 81270184, 31371481, 81370550, 81570530]
- National Science and Technology Support Project [2013YQ03092305, 2014BAI02B01, 2015BAI08B01]
The innate immune system is responsible for sensing pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) by several types of germline-encoded pattern recognition receptors (PRRs). It has the capacity to help the human body maintain homeostasis under normal conditions. However, in pathological conditions, PAMPs or DAMPs trigger aberrant innate immune and inflammatory responses and thus negatively or positively influence the progression of cancer and cardiometabolic diseases. Interestingly, we found that some elements of innate immune signaling are involved in these diseases partially via immune-independent manners, indicating a deeper understanding of the function of innate immune signaling in these diseases is urgent. In this review, we summarize the primary innate immune signaling pathways and their association with cancer and cardiometabolic diseases, with the aim of providing effective therapies for these diseases. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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