期刊
TOXINS
卷 9, 期 4, 页码 -出版社
MDPI AG
DOI: 10.3390/toxins9040135
关键词
parasitoid wasps; hosts; venom proteins; venom gland; transcriptomics; proteomics
资金
- NSFC [31620103915]
- China National Special Agricultural Research Projects for Public Welfare [201303017]
- National Natural Science Foundation of China [31472038]
- National Science Fund for Innovative Research Groups of Biological Control [31321063]
- Rice Pests Management Research Group of the Agricultural Science and Technology Innovation Program
Many species of endoparasitoid wasps provide biological control services in agroecosystems. Although there is a great deal of information on the ecology and physiology of host/parasitoid interactions, relatively little is known about the protein composition of venom and how specific venom proteins influence physiological systems within host insects. This is a crucial gap in our knowledge because venom proteins act in modulating host physiology in ways that favor parasitoid development. Here, we identified 37 possible venom proteins from the polydnavirus-carrying endoparasitoid Cotesia chilonis by combining transcriptomic and proteomic analyses. The most abundant proteins were hydrolases, such as proteases, peptidases, esterases, glycosyl hydrolase, and endonucleases. Some components are classical parasitoid venom proteins with known functions, including extracellular superoxide dismutase 3, serine protease inhibitor and calreticulin. The venom contains novel proteins, not recorded from any other parasitoid species, including tolloid-like proteins, chitooligosaccharidolytic beta-N-acetylglucosaminidase, FK506-binding protein 14, corticotropin-releasing factor-binding protein and vascular endothelial growth factor receptor 2. These new data generate hypotheses and provide a platform for functional analysis of venom components.
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