期刊
TOXINS
卷 9, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/toxins9030075
关键词
acute oral toxicity; European molluscs; lethal dose 50 (LD50); No Observed Adverse Effect Level (NOAEL); risk assessment; tetrodotoxin
资金
- FEDER
- CDTI
- Ministerio de Economia, Industria y Competitividad [AGL2014-58210-R, AGL2016-78728-R, ISCIII/PI16/01830, RTC-2016-5507-2]
- CDTI under ISIP Programme, Spain [IDI-20130304 APTAFOOD, ITC-20161072]
- European Union [312184 PHARMASEA]
Tetrodotoxin (TTX) is starting to appear in molluscs from the European waters and is a hazard to seafood consumers. This toxin blocks sodium channels resulting in neuromuscular paralysis and even death. As a part of the risk assessment process leading to a safe seafood level for TTX, oral toxicity data are required. In this study, a 4-level Up and Down Procedure was designed in order to determine for the first time the oral lethal dose 50 (LD50) and the No Observed Adverse Effect Level (NOAEL) in mice by using an accurate well-characterized TTX standard.
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