期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 17, 期 8, 页码 845-857出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026616666160927150452
关键词
Andrographis paniculata; Terpenoid; Andrographolide; Pharmacological activities
资金
- DST Indo-Srilankan DST- MTR [DST/INT/SLP/P-007/2012]
- Indo-European - Marie Curie IRSES Grant [PIRSES-GA-2013-612131]
Andrographis paniculata (A. paniculata) is a medicinal plant used in the Indian and Chinese traditional medicinal systems for its various beneficial properties of therapeutics. This is due to the presence of a diterpene lactone called `andrographolide'. Several biological activities like antiinflammatory, antitumour, anti-hyperglycaemic, anti-fertility, antiviral, cardio protective and hepatoprotective properties are attributed to andrographolide and its natural analogs. The studies have shown that not only this diterpene lactone (andrographolide), but also other related terpenoid analogs from A. paniculata could be exploited for disease prevention due to their structural similarity with diverse pharmacological activities. Several scientific groups are trying to unveil the underlying mechanisms involved in these biological actions brough aout by andrographolide and its analogs. This review aims at giving an overview on the therapeutical and/or pharmacological activities of andrographolide and its derivatives and also exemplify the underlying mechanisms involved.
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