期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
卷 1862, 期 4, 页码 371-381出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbalip.2016.07.014
关键词
Lipoxygenase; Lipoxins; Macrophages; Inflammation; Resolution; Lipid oxidation
资金
- Deutsche Forschungsgemeinschaft [CRC1181]
- Else Kroner Fresenius Stiftung [2013_A274]
- European Union [ERC StG 640087 - SOS]
12/15-Lipoxygenase (12/15-LOX) mediates the enzymatic oxidation of polyunsaturated fatty acids, thereby contributing to the generation of various bioactive lipid mediators. Although 12/15-LOX has been implicated in the pathogenesis of multiple chronic inflammatory diseases, its physiologic functions seem to include potent immune modulatory properties that physiologically contribute to the resolution of inflammation and the clearance of inflammation-associated tissue damage. This review aims to give a comprehensive overview about our current knowledge on the role of this enzyme during the regulation of inflammation and immunity. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder. (C) 2016 Elsevier B.V. All rights reserved.
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