期刊
CELL PROLIFERATION
卷 50, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/cpr.12326
关键词
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类别
资金
- National Natural Science Foundation of China (NSFC) [81560502]
- National Natural Science Foundation of Yunnan Province [2013FB044, 2014FB008]
- Health Science and Technology Project of Yunnan Province [2016NS005]
- Education Department Fund of Yunnan Province [2014Y165, 2015Z082]
- Science and Technology Innovation Team Building Project of Kunming Medical University [CXTD201601]
- Doctoral Graduate Academic Newcomer Award of Yunnan Province
- Graduate Innovation Fund [2016D02, 2016D11, 2016S76]
Keloid scarring is a dermal fibroproliferative response characterized by excessive and progressive deposition of collagen; aetiology and molecular pathology underlying keloid formation and progression remain unclear. Genetic predisposition is important in the pathogenic processes of keloid formation, however, environmental factors and epigenetic mechanisms may also play pivotal roles. Epigenetic modification is a recent area of investigation in understanding the molecular pathogenesis of keloid scarring and there is increasing evidence that epigenetic changes may play a role in induction and persistent activation of fibroblasts in keloid scars. Here we have reviewed three epigenetic mechanisms: DNA methylation, histone modification and the role of non-coding RNAs. We also review the evidence that these mechanisms may play a role in keloid formation - in future, it may be possible that epigenetic markers may be used instead of prognostic or diagnostic markers here. However, there is a significant amount of work required to increase our current understanding of the role of epigenetic modification in keloid disease.
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