期刊
ECOLOGICAL INDICATORS
卷 75, 期 -, 页码 126-131出版社
ELSEVIER
DOI: 10.1016/j.ecolind.2016.12.006
关键词
Fenoxaprop-ethyl; Earthworm; Toxicity; Degradation; Chiral
资金
- National Natural Science Foundation of China [21337005, 21277171]
- program for Changjiang Scholars and Innovative Research Team in University
- New-Star of Science and Technology
- Beijing Nova program [YETP0323]
- Chinese Universities Scientific Fund [2015LX005]
- Beijing Advanced Innovation Center for Food Nutrition and Human Health
The enantioselective degradation of fenoxaprop-ethyl in ecological indicator earthworm was studied and the main metabolites (fenoxaprop, 6-chloro-2,3-dihydrobenzoxazol-2-one, ethyl-2-(4hydroxyphenoxy)propanoate, 2-(4-hydroxyphenoxy)propanoic acid) were also monitored on an enantiomeric level. The individual enantiomers of fenoxaprop-ethyl and its three chiral metabolites were prepared to study the acute toxicity to earthworm. Chiral analysis methods were set up based on HPLC-MS/MS with chiralpak IC chiral column. Fenoxaprop-ethyl was not found in earthworms, while the primary metabolite fenoxaprop was in relatively high levels indicating a quick hydrolysis degradation. Fenoxaprop was accumulated almost exclusively with R-enantiomer in earthworms and the bio-concentration factors of R-fenoxaprop and S-fenoxaprop were 139 and 0.17 respectively with the enantiomer fraction (EF) values about 0.99. The degradation of R-fenoxaprop in earthworms followed first-order kinetics with half-life of 1.82 day. The other metabolites could not be detected in earthworms. The calculated LC50 values showed ecological indicator earthworm was more sensitive to the four metabolites than fenoxaprop-ethyl. Furthermore, earthworm was more sensitive to the R-form of the chiral metabolites than the S-form and rac-form. The results suggested metabolites and enantioselectivity should be taken into consideration to better predict the exposure concentration and apply ecological indicators in toxicological studies. 2016 Elsevier Ltd. All rights reserved.
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