期刊
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
卷 87, 期 4, 页码 343-348出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2016.12.012
关键词
Klebsiella pneumoniae; ST307; bla(Kpc); Carbapenem resistance; Tn4401a; IncX3
资金
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A120843]
- Korea Health Promotion Institute [HI12C0756090016] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Over a 5-month period between the end of June and the beginning of November in 2015, a KPC-producing Enterobacteriaceae outbreak occurred in a general hospital in Busan, South Korea, being associated with a total of 50 clinical isolates from 47 patients. Multilocus sequence typing and pulsed-field gel electrophoresis were carried out for strain typing and whole-genome sequencing was performed to characterize the plasmids. A clonal spread of K. pneumoniae sequence type 307 (ST307) carrying a self-transferable IncX3-type plasmid harboring bla(Kpc-2) was responsible for the outbreak. Sporadic emergence of K. pneumoniae ST697 carrying an IncFll-type plasmid and a ST11 isolate harboring a small plasmid devoid of any known origin of replication were observed to be associated with bla(Kpc-3), but no further dissemination of these strains was identified. The results indicated a healthcare-associated infection associated with a blaocharboring plasmid dissemination and a clonal spread of KPC-producing Enterobacteriaceae. (C) 2016 Elsevier Inc. All rights reserved.
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