期刊
NATURE PLANTS
卷 3, 期 4, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nplants.2017.36
关键词
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资金
- [26113007]
- [26116003]
- [16H06159]
- [15K14444]
- [16J07290]
- Grants-in-Aid for Scientific Research [16H06159, 15K14444, 16J07290] Funding Source: KAKEN
It remains unclear how post-transcriptional gene silencing (PTGS) in plants discriminates aberrant RNAs from canonical messenger RNAs (mRNAs). The key step of plant PTGS is the conversion of aberrant RNAs into double-stranded RNAs by RNA-DEPENDENT RNA POLYMERASE6 (RDR6). Here, we show that RDR6 itself selects aberrant poly(A)-less mRNAs over canonical polyadenylated mRNAs as templates at the initiation step of complementary strand synthesis. This mechanism can be viewed as an innate safeguard against 'self-attack' by PTGS.
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