期刊
ACS NANO
卷 11, 期 4, 页码 3922-3932出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.7b00312
关键词
cholangiocarcinoma; aggregation-induced emission; targeted fluorescence imaging; photodynamic therapy; targeted therapy
类别
资金
- State Key Laboratory of Luminescent Materials and Devices (South China University of Technology) [2017-skllmd-02]
- National Science Foundation of China [81372668, 81502527]
- Natural Science Foundation of Hubei Province, China [2015CFB527]
- Fundamental Research Funds for the Central Universities, China [2014QN064]
- Union Hospital, Tongji Medical College, HUST [02.03.2015-74]
- Singapore National Research Foundation [R279-000-483-281, R279-000-444-281]
- National University of Singapore [R279-000-482-133]
Photodynamic therapy (PDT) is a palliative technique that can improve median survival with minimal invasion for cholangiocarcinoma (CC) patients. An ideal photosensitizer (PS) is critical to guarantee the efficacy of PDT. However, conventional PSs have some obvious drawbacks, such as lack of specificity and easy aggregation in aqueous media that limit their further application in the clinic. We herein fully take advantage of a red emissive aggregation induced emission (AIE) PS to fabricate integrin alpha(nu)beta(3) targeted organic AIE dots for image-guided PDT via a simple and straightforward one-step strategy. The obtained AIE dots exhibit high specificity to CC as well as excellent antitumor effect both in vitro and in vivo. Different from conventional PSs and previously reported PS-loaded nanostructures, the AIE dots do not suffer from aggregation caused fluorescence quenching and reduction in reactive oxygen species production when the AIE PS molecules are in an aggregated state. The significant antitumor effect, as well as good biocompatibility and negligible toxicity, makes the AIE, dots promising for future translational research in CC diagnosis and therapy.
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