期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 37, 期 -, 页码 19-25出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2016.11.022
关键词
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资金
- UK Biotechnology and Biological Sciences Research Council [BB/M006832/1]
- Royal Society for a Wolfson Research Merit Award
- Centre of Excellence for Biocatalysis, Biotransformations and Biomanufacture (CoEBio3)
- Pfizer
- Johnson Matthey
- AstraZeneca
- BBSRC [BB/M006611/1, BB/M006832/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M006611/1, 1394023, BB/M006832/1] Funding Source: researchfish
Imine reductases (IREDs) have emerged as a valuable new set of biocatalysts for the asymmetric synthesis of optically active amines. The development of bioinformatics tools and searchable databases has led to the identification of a diverse range of new IRED biocatalysts that have been characterised and employed in different synthetic processes. This review describes the latest developments in the structural and mechanistic aspects of IREDs, together with synthetic applications of these enzymes, and identifies ongoing and future challenges in the field.
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