期刊
PROTEIN & CELL
卷 9, 期 4, 页码 322-332出版社
HIGHER EDUCATION PRESS
DOI: 10.1007/s13238-017-0425-3
关键词
regulatory T cells; thymus; differentiation; IL-2; IL-15
类别
资金
- Fondation pour la Recherche Medicale [FRM-DEQ20160334920]
- Agence Nationale pour la Recherche [ANR-16-CE15-0015-01]
- IdEx Toulouse
- Agence Nationale de la Recherche (ANR) [ANR-16-CE15-0015] Funding Source: Agence Nationale de la Recherche (ANR)
Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immune-system to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15. The more recently appreciated involvement of TGF-beta in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process.
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