期刊
BIOORGANIC CHEMISTRY
卷 71, 期 -, 页码 19-29出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2017.01.009
关键词
Bis-aldehydes; Malononitrile; Bis-arylidenemalononitriles; Multicomponent reactions; Bis(1,4-dihydropyrano[2,3-c]pyrazole-5carbonitrile); Docking studies; Cytotoxic assay; MTT
资金
- Alexander von Humboldt Foundation
An efficient route for the synthesis of novel bis(1,4-dihydropyrano[2,3-c] pyrazole-5-carbonitrile) derivatives is reported. The synthetic pathway involves one pot, synthesis of bis-aldehydes, malononitrile, and pyrazolone in the presence of pyridine. The anticancer activity of the synthesized products against MCF7, HEPG2, and A549 cell lines was assessed. Docking studies were performed and indicated the best binding mode compared to the standard ligand sorafenib. (C) 2017 Elsevier Inc. All rights reserved.
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