期刊
POLYMERS
卷 9, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/polym9060189
关键词
poly (lactic-co-glycolic acid); barrier membranes; bone grafts; drug delivery carriers; periodontal tissue regeneration
资金
- National Natural Science Foundation of China [30973314]
- Australian Research Council [ARC DECRA: DE120101666]
Periodontal tissue regeneration is the ultimate goal of the treatment for periodontitis-affected teeth. The success of regenerative modalities relies heavily on the utilization of appropriate biomaterials with specific properties. Poly (lactic-co-glycolic acid) (PLGA), a synthetic aliphatic polyester, has been actively investigated for periodontal therapy due to its favorable mechanical properties, tunable degradation rates, and high biocompatibility. Despite the attractive characteristics, certain constraints associated with PLGA, in terms of its hydrophobicity and limited bioactivity, have led to the introduction of modification strategies that aimed to improve the biological performance of the polymer. Here, we summarize the features of the polymer and update views on progress of its applications as barrier membranes, bone grafts, and drug delivery carriers, which indicate that PLGA can be a good candidate material in the field of periodontal regenerative medicine.
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