期刊
POLYMERS
卷 9, 期 11, 页码 -出版社
MDPI AG
DOI: 10.3390/polym9110601
关键词
nitric oxide donors; N-diazeniumdiolates; drug release; antimicrobial surfaces; biofilm prevention
资金
- EPSRC DTA studentship [EP/MO27325/1]
- BBSRC [BB/R012415/1] Funding Source: UKRI
- EPSRC [EP/N51004X/1, EP/M027325/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/M027325/1, EP/N51004X/1, 1646949] Funding Source: researchfish
- National Biofilms Innovation Centre [NBIC Co-Director Raval] Funding Source: researchfish
The ability of nitric oxide (NO)-releasing polymer coatings to prevent biofilm formation is described. NO-releasing coatings on (poly(ethylene terephthalate) (PET) and silicone elastomer (SE)) were fabricated using aminosilane precursors. Pristine PET and SE were oxygen plasma treated, followed by immobilisation of two aminosilane molecules: N-(3-(trimethoxysilyl)propyl)diethylenetriamine (DET3) and N-(3-trimethoxysilyl)propyl)aniline (PTMSPA). N-diazeniumdiolate nitric oxide donors were formed at the secondary amine sites on the aminosilane molecules producing NO-releasing polymeric coatings. The NO payload and release were controlled by the aminosilane precursor, as DET3 has two secondary amine sites and PTMSPA only one. The antibacterial efficacy of these coatings was tested using a clinical isolate of Pseudomonas aeruginosa (PA14). All NO-releasing coatings in this study were shown to significantly reduce P. aeruginosa adhesion over 24 h with the efficacy being a function of the aminosilane modification and the underlying substrate. These NO-releasing polymers demonstrate the potential and utility of this facile coating technique for preventing biofilms for indwelling medical devices.
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