期刊
CURRENT OPINION IN IMMUNOLOGY
卷 45, 期 -, 页码 132-140出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2017.03.005
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资金
- NHMRC Principal Research Fellowship [1042925]
- NHMRC Program [113904]
- NHMRC Project [1127157, 1124681]
- National Health and Medical Research Council of Australia [1127157, 1124681] Funding Source: NHMRC
Immunological memory is a cornerstone of adaptive immune responses in higher vertebrates. The remarkable ability to generate memory cells following Ag exposure, in the context of natural infection or immunization, provides long-lived protection against infectious diseases, often for the hosts' lifetime. Indeed, the generation of memory B cells and long-lived plasma cells underpins the success of most vaccines. The concept of immunological memory is not new-it was first proposed nearly 2500 years ago. While our understanding of the complexities of humoral and cell-mediated memory continues to evolve, important aspects of this process remain unresolved. Here, we will provide an overview of recent advances in B-cell memory in mice and humans, and in health and disease.
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