期刊
POLYMERS
卷 9, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/polym9070249
关键词
sialic acids; biointerface materials; cancer detection and imaging; drug delivery
资金
- Major State Basic Research Development Program of China [2013CB933002]
- China National Funds for Distinguished Young Scientists [51325302]
- Science and Technology Research Project of Jiangxi Education Department [GJJ161141]
- Hubei Provincial Department of Education through the Chutian Scholar Program
Sialic acids (SAs) are typically found as terminal monosaccharides attached to cell surface glycoconjugates, which play crucial roles in various biological processes, and aberrant sialylation is closely associated with many diseases, particularly cancers. As SAs are overexpressed in tumor-associated glycoproteins, the recognition and specific binding of SA are crucial for monitoring, analyzing and controlling cancer cells, which would have a considerable impact on diagnostic and therapeutic application. However, both effective and selective recognition of SA on the cancer cell surface remains challenging. In recent years, SA-targeted biointerface materials have attracted great attention in various bio-applications, including cancer detection and imaging, drug delivery for cancer therapy and sialylated glycopeptide separation or enrichment. This review provides an overview of recent advances in SA-targeted biointerface materials and related bio-applications.
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