期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 152, 期 -, 页码 229-237出版社
ELSEVIER
DOI: 10.1016/j.colsurfb.2017.01.019
关键词
Aerogel structure; Drug release; Kinetics; NMR spectroscopy
资金
- Hungarian Science Foundation [OTKA: NK-105156]
- University of Debrecen [RH/751/2015]
- Spanish National Plan of Research [CTQ2014-56324]
- NEW NATIONAL EXCELLENCE PROGRAM of the Ministry of Human Capacities of Hungary
- EU
- European Regional Development Fund [GINOP-2.3.2-15-2016-00008]
- [TAMOP-4.2.4A/2-11/1-2012-0001]
- [TAMOP-4.2.4B/2-11/1-2012-0001]
Specific features of a silica-gelatin aerogel (3 wt.% gelatin content) in relation to drug delivery has been studied. It was confirmed that the release of both ibuprofen (IBU) and ketoprofen (KET) is about tenfold faster from loaded silica-gelatin aerogel than from pure silica aerogel, although the two matrices are structurally very similar. The main goal of the study was to understand the mechanistic background of the striking difference between the delivery properties of these closely related porous materials. Hydrated and dispersed silica-gelatin aerogel has been characterized by NMR cryoporometry, diffusiometry and relaxometry. The pore structure of the silica aerogel remains intact when it disintegrates in water. In contrast, dispersed silica-gelatin aerogel develops a strong hydration sphere, which reshapes the pore walls and deforms the pore structure. The drug release kinetics was studied on a few minutes time scale with 1 s time resolution. Simultaneous evaluation of all relevant kinetic and structural information confirmed that strong hydration of the silica-gelatin skeleton facilitates the rapid desorption and dissolution of the drugs from the loaded aerogel. Such a driving force is not operative in pure silica aerogels. (C) 2017 Elsevier B.V. All rights reserved.
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