期刊
CHEMICO-BIOLOGICAL INTERACTIONS
卷 267, 期 -, 页码 104-115出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2016.05.028
关键词
Quorum sensing; Quorum quenching; Enzyme; Lactonase; Virulence; Biofilm
资金
- Direction Generale de l'Armement (DGA, France)
- Emplois Jeunes Doctor ants
Numerous bacteria use quorum sensing (QS) to synchronize their behavior and monitor their population density. They use signaling molecules known as autoinducers (AI's) that are synthesized and secreted into their local environment to regulate QS-dependent gene expression. Among QS-regulated pathways, biofilm formation and virulence factor secretion are particularly problematic as they are involved in surface -attachment, antimicrobial agent resistance, toxicity, and pathogenicity. Targeting QS represents a promising strategy to inhibit undesirable bacterial traits. This strategy, referred to as quorum quenching (QQ), includes QS-inhibitors and QQ enzymes. These approaches are appealing because they do not directly challenge bacterial survival, and consequently selection pressure may be low, yielding a lower occurrence of resistance. QQ enzymes are particularly promising because they act extracellularly to degrade AI's and can be used in catalytic quantities. This review draws an overview of QQ enzyme related applications, covering several economically important fields such as agriculture, aquaculture, biofouling and health issues. Finally, the possibility of resistance mechanism occurrence to QQ strategies is discussed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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