期刊
BIOCONJUGATE CHEMISTRY
卷 28, 期 4, 页码 1189-1193出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.7b00046
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- NWO Gravity Program Institute for Chemical Immunology (ICI)
Genetically encoded tyrosine (Y-tag) can be utilized as a latent anchor for inducible and site-selective conjugation. Upon oxidation of tyrosine with mushroom tyrosinase, strain-promoted cycloaddition (SPOCQ) of the resulting 1,2-quinone with various. bicyclo[6.1.0]nonyne (BCN) derivatives led to efficient conjugation. The method was applied for fluorophore labeling of laminarinase A and for the site-specific preparation of an antibody drug conjugate.
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