期刊
CLINICAL CANCER RESEARCH
卷 23, 期 7, 页码 1638-1646出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-16-2411
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资金
- Cancer Research UK [C596/A20921, C29717/A17263, C596/A18076]
- Wellcome Trust [10372/Z/14/Z]
- Chief Scientists Office of the Scottish Government through the Scottish Genomes Partnership-SEHHD-CSO [1175759/2158447]
- Howat Foundation
- Pancreatic Cancer UK
- MRC [MR/N005813/1] Funding Source: UKRI
- Cancer Research UK [22533, 23526, 17263] Funding Source: researchfish
- Medical Research Council [MR/N005813/1] Funding Source: researchfish
- Pancreatic Cancer UK [FLF2015_04_Glasgow] Funding Source: researchfish
- Wellcome Trust [103721/Z/14/Z] Funding Source: researchfish
Pancreatic cancer has become the third leading cause of cancer-related death, with little improvement in outcomes despite decades of research. Surgery remains the only chance of cure, yet only 20% of patients will be alive at 5 years after pancreatic resection. Few chemotherapeutics provide any improvement in outcome, and even then, for approved therapies, the survival benefits are marginal. Genomic sequencing studies of pancreatic cancer have revealed a small set of consistent mutations found in most pancreatic cancers and beyond that, a low prevalence for targetable mutations. This may explain the failure of conventional clinical trial designs to show any meaningful survival benefit, except in small and undefined patient subgroups. With the development of next-generation sequencing technology, genomic sequencing and analysis can be performed in a clinically meaningful turnaround time. This can identify therapeutic targets in individual patients and personalize treatment selection. Incorporating preclinical discovery and molecularly guided therapy into clinical trial design has the potential to significantly improve outcomes in this lethal malignancy. In this review, we discuss the findings of recent large-scale genomic sequencing projects in pancreatic cancer and the potential relevance of these data to therapeutic development.
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