4.8 Article

Rabies Virus-Inspired Silica-Coated Gold Nanorods as a Photothermal Therapeutic Platform for Treating Brain Tumors

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ADVANCED MATERIALS
卷 29, 期 13, 页码 -

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WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201605563

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资金

  1. Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI)
  2. Ministry of Health and Welfare, Republic of Korea [HI15C2221]
  3. Korea Health Promotion Institute [HI15C2221000017] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
  4. National Research Foundation of Korea [22A20154413174, 21A20132112077, 21A20132112043] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Rabies virus-inspired silica-coated gold nanorods are fabricated by mimicking size, shape, surface glycoprotein property and in vivo behavior of the rabies virus. These nanorods not only resemble the appearance of the actual rabies virus but also travel into the brain through the neuronal pathway bypassing the bloodbrain barrier, and moreover respond to near-infrared laser (808 nm) irradiation, emit heat, and effectively suppress brain tumors.

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