期刊
PLOS GENETICS
卷 13, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1006944
关键词
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资金
- MRC [MC_UU_12013/1, MC_UU_12013/4, MC_UU_12013/9]
- MRC [MC_UU_12013/1, MC_UU_12013/4, MC_UU_12013/9] Funding Source: UKRI
- Medical Research Council [MC_UU_12013/9, MC_UU_12013/1] Funding Source: researchfish
The past decade has been proclaimed as a hugely successful era of gene discovery through the high yields of many genome-wide association studies (GWAS). However, much of the perceived benefit of such discoveries lies in the promise that the identification of genes that influence disease would directly translate into the identification of potential therapeutic targets, but this has yet to be realized at a level reflecting expectation. One reason for this, we suggest, is that GWAS, to date, have generally not focused on phenotypes that directly relate to the progression of disease and thus speak to disease treatment.
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