期刊
CELL METABOLISM
卷 25, 期 4, 页码 811-+出版社
CELL PRESS
DOI: 10.1016/j.cmet.2017.03.002
关键词
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资金
- NIH [5R01GM107710, DK 31405]
- JPB Foundation
- Canadian Institutes of Health Research
- Human Frontier Science Program
Cold and other environmental factors induce browning'' of white fat depots-development of beige adipocytes with morphological and functional resemblance to brown fat. Similar to brown fat, beige adipocytes are assumed to express mitochondrial uncoupling protein 1 (UCP1) and are thermogenic due to the UCP1-mediated H+ leak across the inner mitochondrial membrane. However, this assumption has never been tested directly. Herein we patch clamped the inner mitochondrial membrane of beige and brown fat to provide a direct comparison of their thermogenic H+ leak (I-H). All inguinal beige adipocytes had robust UCP1-dependent I-H comparable to brown fat, but it was about three times less sensitive to purine nucleotide inhibition. Strikingly, only similar to 15% of epididymal beige adipocytes had I-H, while in the rest UCP1-dependent IH was undetectable. Despite the absence of UCP1 in the majority of epididymal beige adipocytes, these cells employ prominent creatine cycling as a UCP1-independent thermogenic mechanism.
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