期刊
PLOS GENETICS
卷 13, 期 4, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1006528
关键词
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资金
- National Heart, Lung, and Blood Institute
- National Institutes of Health
- U.S. Department of Health and Human Services
- Ejner Danielsens Foundation
- Academy of Finland [102318, 104781, 120315, 123885, 129619, 286284, 134309, 126925, 121584, 124282, 129378, 117787, 250207, 258753, 41071, 77299, 124243, 1114194, 24300796]
- Accare Center for Child and Adolescent Psychiatry
- Action on Hearing Loss [G51]
- Agence Nationale de la Recherche
- Agency for Health Care Policy Research [HS06516]
- Age UK Research into Ageing Fund
- Ake Wiberg Foundation
- ALF/LUA Research Grant in Gothenburg
- ALFEDIAM
- ALK-Abello' NS (Horsholm, Denmark)
- American Heart Association [13P0ST16500011, 10SDG269004]
- Ardix Medical
- Arthritis Research UK
- Association Diabete Risque Vasculaire
- AstraZeneca
- Australian Associated Brewers
- Australian National Health and Medical Research Council [241944, 339462, 389927, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 552485, 552498]
- Avera Research Institute
- Bayer Diagnostics
- Becton Dickinson
- Biobanking and Biomolecular Resources Research Infrastructure (BBMRI NL) [184.021.007]
- Biocentrum Helsinki
- Boston Obesity Nutrition Research Center [DK46200]
- British Heart Foundation [RG/10/12/28456, SP/04/002]
- Canada Foundation for Innovation
- Canadian Institutes of Health Research [FRN-CCT-83028]
- Cancer Research UK
- Cardionics
- Center for Medical Systems Biology
- Center of Excellence in Complex Disease Genetics and SALVECenter of Excellence in Genomics (EXCEGEN)
- Chief Scientist Office of the Scottish Government
- City of Kuopio
- Cohortes Sante TGIR
- Contrat de Projets Etat-Region
- Croatian Science Foundation [8875]
- Danish Agency for Science, Technology and Innovation
- Danish Council for Independent Research [DFF-1333-00124, DFF-1331-007308]
- Danish Diabetes Academy
- Danish Medical Research Council
- Department of Psychology and Education of the VU University Amsterdam
- Diabetes Hilfs- und Forschungsfonds Deutschland
- Dutch Brain Foundation
- Dutch Ministry of Justice
- Emil Aaltonen Foundation
- Erasmus Medical Cente
- Erasmus University
- Estonian Government [IUT20-60, IUT24-6]
- Estonian Ministry of Education and Research [3.2.0304.11-0312]
- European Commission [230374, 284167, 323195, 692145, FP7 EurHEALTHAgeing-277849, FP7 BBMRI-LPC 313010, 602633, HEALTH-F2-2008-201865-GEFOS, HEALTH-F4-2007-201413, FP6 LSHM-CT-2004-005272, FP5 QLG2-CT-2002-01254]
- European Regional Development Fund
- European Science Foundation [FP-006, EU/QLRT-2001-01254]
- Faculty of Biology and Medicine of Lausanne
- Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403, 03ZIK012, 031S2061A]
- Federal State of Mecklenburg - West Pomerania
- Federation Francaise de Cardiologie
- Finnish Cultural Foundation
- Finnish Diabetes Association
- Finnish Foundation of Cardiovascular Research
- Finnish Heart Association
- Food Standards Agency
- Fondation de France
- Fonds Sante
- Genetic Association Information Network of the Foundation for the National Institutes of Health
- German Diabetes Association
- German Federal Ministry of Education and Research [01ER1206, 01ER1507]
- German Research Council [SFB-1052, SPP 1629 TO 718/2-1]
- GlaxoSmithKline
- Goran Gustafssons Foundation
- Goteborg Medical Society
- Health and Safety Executive
- Heart Foundation of Northern Sweden
- Icelandic Heart Association
- Icelandic Parliament
- Imperial College Healthcare NHS Trust
- INSERM, Reseaux en Sante Publique, Interactions entre les determinants de la sante
- Interreg IV Oberrhein Program
- Italian Ministry of Economy and Finance
- Italian Ministry of Health [ICS110.1/RF97.71]
- John D and Catherine T MacArthur Foundation
- Juho Vainio Foundation
- King's College London
- Kjell och Marta Beijers Foundation
- Kuopio University Hospital
- Kuopio, Tampere and Turku University Hospital Medical Funds [X51001]
- Leiden University Medical Center
- Lilly
- LMUinnovativ
- Lundbeck Foundation
- Lundberg Foundation
- Medical Research Council of Canada
- MEKOS Laboratories (Denmark)
- Merck Sante
- Mid-Atlantic Nutrition Obesity Research Center [P30 DK72488]
- Ministere de l'Economie, de l'Innovation et des Exportations
- Ministry for Health, Welfare and Sports of the Netherlands
- Ministry of Cultural Affairs of the Federal State of Mecklenburg-West Pomerania
- Ministry of Education and Culture of Finland [627]
- Ministry of Education, Culture and Science of the Netherlands
- MRC Human Genetics Unit
- MRC-GlaxoSmithKline Pilot Programme Grant [G0701863]
- Municipality of Rotterdam
- Netherlands Bioinformatics Centre [2008.024]
- Netherlands Consortium for Healthy Aging [050-060-810]
- Netherlands Genomics Initiative
- Netherlands Organisation for Health Research and Development [904-61-090, 985-10002, 904-61-193, 480-04-004, 400-05-717, Addiction-31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192, 2010/31471/ZONMVV]
- Netherlands Organisation for Scientific Research [10-000-1002, GB -MW 940-38-011, 100-001-004, 60-60600-97-118, 26198-710, GB-MaGW 480-01-006, GB-MaGW 480-07-001, GB-MaGW 452-04-314, GB-MaGW 45206-004, 175.010.2003.005, 175.010.2005.011, 481-08-013, 480-05-003, 911-03-012]
- Neuroscience Campus Amsterdam
- NHS Foundation Trust
- Novartis Pharmaceuticals
- Novo Nordisk
- Office National Interprofessionel des Vins
- Paavo Nurmi Foundation
- PahIssons Foundation
- Paivikki and Sakari Sohlberg Foundation
- Pierre Fabre
- Republic of Croatia Ministry of Science, Education and Sport [108-1080315-0302]
- Research Centre for Prevention and Health, the Capital Region for Denmark
- Research Institute for Diseases in the Elderly [014-93-015, RIDE2]
- Roche
- Russian Foundation for Basic Research [NWO-RFBR 047.017.043]
- Rutgers University Cell and DNA Repository [NIMH U24 MH068457-06]
- Sanofi-Aventis
- Scottish Executive Health Department [CZD/16/6]
- Siemens Healthcare
- Social Insurance Institution of Finland [4/26/2010]
- Social Ministry of the Federal State of Mecklenburg-West Pomerania
- Societe Francophone du Diabete
- State of Bavaria
- Stroke Association
- Swedish Diabetes Association
- Swedish Foundation for Strategic Research
- Swedish Heart-Lung Foundation [20140543]
- Swedish Research Council [2015-03657]
- Swedish Medical Research Council [K2007-66X-20270-013, 2011-2354]
- Swedish Society for Medical Research
- Swiss National Science Foundation [33CSC0-122661, 33CS30-139468, 33CS30-148401]
- Tampere Tuberculosis Foundation
- Marcus Borgstrom Foundation
- Royal Society
- Wellcome Trust [084723/Z/08/Z, 088869/B/09/ Z, 090532, 091551, 098051, 098381]
- Timber Merchant Vilhelm Bangs Foundation
- Topcon
- Topcon
- Torsten and Ragnar Soderberg's Foundation
- UK Department of Health
- UK Diabetes Association
- UK Medical Research Council [MC_U106179471, G0500539, G0600705, G0601966, G0700931, G1002319, K013351, MC_UU_12019/1]
- UK National Institute for Health Research BioResource Clinical Research Facility and Biomedical Research Centre
- UK National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre
- UK National Institute for Health Research [RP-PG 0407 -10371]
- Umea University Career Development Award
- United States - Israel Binational Science Foundation Grant [2011036]
- University Hospital Oulu [75617]
- University Medical Center Groningen
- University of Tartu [SP1GVARENG]
- National Institutes of Health [AG13196, CA047988, HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, HHSC271201100004C, HHSN268200900041C, HHSN268201300025C, HHSN268201300026C]
- Vastra Gotaland Foundation
- Velux Foundation
- Veterans Affairs [1 IK2 BX001823]
- Vleugels Foundation
- VU University's Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam [HEALTH-F4-2007-201413)]
- Wissenschaftsoffensive TMO
- Yrjo Jahnsson Foundation
- [FP6 LSHG-CT-2006-01947]
- [FP7 HEALTH-F4-2007-201413]
- [FP7 279143, FP7 201668]
- [FP7 305739]
- [FP6 LSHG-CT-2006-018947]
- [QLG1-CT-2001-01252]
- [R01-HL087641]
- [R01-HL59367]
- [R01HL-086694]
- [R24-HD050924]
- [U01-HG-004402]
- [HHSN268200625226C]
- [UL1-RR025005]
- [UL1-TR-001079]
- [UL1-TR-00040]
- [AA07535]
- [AA10248]
- [AA11998]
- [AA13320]
- [AA13321]
- [AA13326]
- [AA14041]
- [AA17688]
- [DA12854]
- [MH66206]
- [R01-D004215701A]
- [R01-DK075787]
- [R01-DK089256]
- [U01-HG007376]
- [5R01-HL08767902]
- [5R01-MH63706:02]
- [HG004790]
- [N01-WH22110]
- [U01-HG007033]
- [UM1CA182913]
- [24152]
- [32100-2]
- [32105-6]
- [32108-9]
- [32111-13]
- [32115]
- [32118-32119]
- [32122]
- [42107-26]
- [4212932]
- [44221]
- [HHSN268201300028C]
- [HHSN268201300029C]
- [HHSN2682015000011]
- [HL36310]
- [HG002651]
- [HL034594]
- [HL054457]
- [HL054481]
- [HL071981]
- [HL084729]
- [HL119443]
- [HL126024]
- [N01-AG12100]
- [N01-AG12109]
- [N01-HC25195]
- [N01-HC55015]
- [N01-HC55016]
- [N0-1HC55018]
- [N01-HC55019]
- [N01-HC55020]
- [N0-1HC55021]
- [R01-HD057194]
- [N01-HC55022]
- [N01-HD95159]
- [N0-1HD95160]
- [N01-HD95161]
- [N01-HD95162]
- [N01-HD95163]
- [N01-HD95164]
- [N01-HD95165]
- [N01-HD95166]
- [N01-HD95167]
- [N01-HD95168]
- [N01-HD95169]
- [N01-HG65403]
- [N02-HL64278]
- [HL087660]
- [HL100245]
- [R01DK089256]
- [2T32HL007055-36]
- [U01-HL072515-06]
- [U01-HL84756]
- [NIA-U01AG009740]
- [RC2-AG036495]
- [RC4-AG039029]
- [R03-AG046389]
- [263-MA-410953]
- [263-MD-9164]
- [263-MD-821336]
- [U01-HG004802]
- [R37CA54281]
- [RO1CA63]
- [P01CA33619]
- [U01-CA136792]
- [U01-CA98758]
- [RC2-MH089951]
- [MH085520]
- [R01-D0042157-01A]
- [MH081802]
- [1RC2-MH089951]
- [1RC2-MH089995]
- [1RL1MH08326801]
- [HHSN268201300027C]
- [R01-DK8925601]
- [R01-HL088451]
- [R01-HL117078]
- [R01-DK062370]
- [R01-DK072193]
- [DK091718]
- [DK100383]
- [DK078616]
- [1Z01-HG000024]
- British Heart Foundation [RG/10/12/28456] Funding Source: researchfish
- Medical Research Council [MC_UU_12015/1, MC_UU_12019/1, MC_UU_12015/2, MC_PC_13048, MC_U106179473, MC_UU_12013/1, MC_PC_13046, MR/K002414/1, MC_UU_12015/3, MR/K013351/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10099] Funding Source: researchfish
- Novo Nordisk Fonden [NNF14OC0009883, NNF14OC0011039, NNF13OC0005785, NNF17OC0026828, NNF13OC0004839, NNF16OC0021214, NNF14OC0010513, NNF15OC0016220] Funding Source: researchfish
- Steno Diabetes Center Copenhagen (SDCC) [SDCC 3.A Complications] Funding Source: researchfish
- Swedish Research Council [2015-03657] Funding Source: Swedish Research Council
- National Institutes of Health Research (NIHR) [RP-PG-0407-10371] Funding Source: National Institutes of Health Research (NIHR)
- Academy of Finland (AKA) [129619, 129619] Funding Source: Academy of Finland (AKA)
- Swiss National Science Foundation (SNF) [33CSC0-122661] Funding Source: Swiss National Science Foundation (SNF)
- MRC [MR/K002414/1, MC_UU_12013/1, MR/K013351/1, MC_UU_12015/1, MC_UU_12015/3, MC_U106179473, MC_UU_12015/2, MC_UU_12019/1] Funding Source: UKRI
- Wellcome Trust [088869/B/09/Z] Funding Source: Wellcome Trust
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
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