期刊
DRUG METABOLISM AND PHARMACOKINETICS
卷 32, 期 1, 页码 100-107出版社
JAPANESE SOC STUDY XENOBIOTICS
DOI: 10.1016/j.dmpk.2016.10.409
关键词
Cytochrome P450; Liver; Gene expression; Sex; Age; Drug metabolism
资金
- Grants-in-Aid for Scientific Research [26360049] Funding Source: KAKEN
Sex and age differences in hepatic expression of drug-metabolizing enzyme genes could cause variations in drug metabolism, but has not been fully elucidated, especially in Asian population. In this study, the global expression of human hepatic genes was analyzed by microarrays in 40 Japanese subjects (27 males and 13 females). Thirty-five sex- biased genes were identified (P < 0.005). Whereas, 60 age-biased genes in two age groups, < 60 years and >= 70 years (P < 0.001), were identified in males. By Gene Ontology analysis, the sex-biased genes were related to protein catabolism and modification, while the age-biased genes were related to transcription regulation and cell death. Quantitative polymerase chain reaction confirmed the female-biased expression of drug-metabolizing enzyme genes BChE, CYP4X1,and SULT1E1 (>= 1.5-fold, P < 0.05). Further analysis of drug-metabolizing enzyme genes indicated that expression of CYP2A6 and CYP3A4 in females in the >= 70 age group was less than in the < 60 age group (>= 1.5-fold, P < 0.05), and this trend was also observed for PXR expression in males (>= 1.5-fold, P < 0.05). The results presented provide important insights into hepatic physiology and function, especially drug metabolism, with respect to sex and age. (C) 2016 The Japanese Society for the Study of Xenobiotics. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据