期刊
AGING-US
卷 9, 期 2, 页码 475-486出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101171
关键词
long intergenic non-protein coding RNA 00858 (LINC00858); hsa-miRNA-422a (miR422a); kallikrein-related peptidase 4 (KLK4); non-small cell lung cancer (NSCLC); tumorigenesis
The expression of long non-coding RNAs (ncRNAs) is dysregulated in non-small cell lung cancer (NSCLC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of long intergenic non-protein coding RNA 00858 (LINC00858) in NSCLC. Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. Moreover, LINC00858 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-422a and thereby modulating the expression of kallikrein- related peptidase 4 (KLK4). In NSCLC patients, high expression of LINC00858 closely correlated with tumor progression. Thus, targeting the ceRNA network involving LINC00858 may be used as a treatment strategy against NSCLC.
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