相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Ensembl Genomes 2016: more genomes, more complexity
Paul Julian Kersey et al.
NUCLEIC ACIDS RESEARCH (2016)
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker et al.
SCIENCE (2016)
Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq
Daesik Kim et al.
GENOME RESEARCH (2016)
High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver et al.
NATURE (2016)
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
John G. Doench et al.
NATURE BIOTECHNOLOGY (2016)
Applications of CRISPR technologies in research and beyond
Rodolphe Barrangou et al.
NATURE BIOTECHNOLOGY (2016)
Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases
Shengdar Q. Tsai et al.
NATURE REVIEWS GENETICS (2016)
Biased and Unbiased Methods for the Detection of Off-Target Cleavage by CRISPR/Cas9: An Overview
Francisco Martin et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
Maximilian Haeussler et al.
GENOME BIOLOGY (2016)
Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
Bernd Zetsche et al.
CELL (2015)
Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design
Behnom Farboud et al.
GENETICS (2015)
A widespread role of the motif environment in transcription factor binding across diverse protein families
Iris Dror et al.
GENOME RESEARCH (2015)
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Benjamin P. Kleinstiver et al.
NATURE (2015)
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran et al.
NATURE (2015)
Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
Xiaoling Wang et al.
NATURE BIOTECHNOLOGY (2015)
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
Miguel A. Moreno-Mateos et al.
NATURE METHODS (2015)
Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach
Raj Chari et al.
NATURE METHODS (2015)
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells
Daesik Kim et al.
NATURE METHODS (2015)
Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design
Behnom Farboud et al.
GENETICS (2015)
CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites
Yuki Naito et al.
BIOINFORMATICS (2015)
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2015)
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
Richard L. Frock et al.
NATURE BIOTECHNOLOGY (2015)
The UCSC Genome Browser database: 2015 update
Kate R. Rosenbloom et al.
NUCLEIC ACIDS RESEARCH (2015)
CRISPR MultiTargeter: A Web Tool to Find Common and Unique CRISPR Single Guide RNA Targets in a Set of Similar Sequences
Sergey V. Prykhozhij et al.
PLOS ONE (2015)
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
Manuel Stemmer et al.
PLOS ONE (2015)
GT-Scan: identifying unique genomic targets
Aidan O'Brien et al.
BIOINFORMATICS (2014)
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
Sangsu Bae et al.
BIOINFORMATICS (2014)
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
Hiroshi Nishimasu et al.
CELL (2014)
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
Seung Woo Cho et al.
GENOME RESEARCH (2014)
CRISPR-P: A Web Tool for Synthetic Single-Guide RNA Design of CRISPR-System in Plants
Yang Lei et al.
MOLECULAR PLANT (2014)
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
Carolin Anders et al.
NATURE (2014)
Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
Xuebing Wu et al.
NATURE BIOTECHNOLOGY (2014)
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
Cem Kuscu et al.
NATURE BIOTECHNOLOGY (2014)
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
John G. Doench et al.
NATURE BIOTECHNOLOGY (2014)
Improved vectors and genome-wide libraries for CRISPR screening
Neville E. Sanjana et al.
NATURE METHODS (2014)
E-CRISP: fast CRISPR target site identification
Florian Heigwer et al.
NATURE METHODS (2014)
CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
Yanni Lin et al.
NUCLEIC ACIDS RESEARCH (2014)
CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing
Tessa G. Montague et al.
NUCLEIC ACIDS RESEARCH (2014)
sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites
Shengsong Xie et al.
PLOS ONE (2014)
Genetic Screens in Human Cells Using the CRISPR-Cas9 System
Tim Wang et al.
SCIENCE (2014)
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Martin Jinek et al.
SCIENCE (2014)
Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila
Xingjie Ren et al.
CELL REPORTS (2014)
COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites
Thomas J. Cradick et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2014)
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
F. Ann Ran et al.
CELL (2013)
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
Prashant Mali et al.
NATURE BIOTECHNOLOGY (2013)
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu et al.
NATURE BIOTECHNOLOGY (2013)
Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Seung Woo Cho et al.
NATURE BIOTECHNOLOGY (2013)
Efficient genome editing in zebrafish using a CRISPR-Cas system
Woong Y. Hwang et al.
NATURE BIOTECHNOLOGY (2013)
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
Vikram Pattanayak et al.
NATURE BIOTECHNOLOGY (2013)
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
Yanfang Fu et al.
NATURE BIOTECHNOLOGY (2013)
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Wenyan Jiang et al.
NATURE BIOTECHNOLOGY (2013)
CRISPR RNA-guided activation of endogenous human genes
Morgan L. Maeder et al.
NATURE METHODS (2013)
Control of DNA minor groove width and Fis protein binding by the purine 2-amino group
Stephen P. Hancock et al.
NUCLEIC ACIDS RESEARCH (2013)
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity
Thomas J. Cradick et al.
NUCLEIC ACIDS RESEARCH (2013)
DNAshape: a method for the high-throughput prediction of DNA structural features on a genomic scale
Tianyin Zhou et al.
NUCLEIC ACIDS RESEARCH (2013)
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali et al.
SCIENCE (2013)
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong et al.
SCIENCE (2013)
Fast and accurate short read alignment with Burrows-Wheeler transform
Heng Li et al.
BIOINFORMATICS (2009)
CRISPR Interference Limits Horizontal Gene Transfer in Staphylococci by Targeting DNA
Luciano A. Marraffini et al.
SCIENCE (2008)
Cytoscape: A software environment for integrated models of biomolecular interaction networks
P Shannon et al.
GENOME RESEARCH (2003)
The UCSC Genome Browser Database
D Karolchik et al.
NUCLEIC ACIDS RESEARCH (2003)
分享论文
