期刊
PLOS COMPUTATIONAL BIOLOGY
卷 13, 期 2, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pcbi.1005382
关键词
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资金
- Division of International Epidemiology and Population Studies
- Fogarty International Center, US National Institutes of Health
- Office of Pandemics and Emerging Threats at the United States Department of Health and Human Services
- Research And Policy in Infectious Diseases Dynamics (RAPIDD) program
- Department of Homeland Security
- European Union
- Gates doctoral fellowship
Seasonal influenza epidemics offer unique opportunities to study the invasion and re-invasion waves of a pathogen in a partially immune population. Detailed patterns of spread remain elusive, however, due to lack of granular disease data. Here we model high-volume city-level medical claims data and human mobility proxies to explore the drivers of influenza spread in the US during 2002-2010. Although the speed and pathways of spread varied across seasons, seven of eight epidemics likely originated in the Southern US. Each epidemic was associated with 1-5 early long-range transmission events, half of which sparked onward transmission. Gravity model estimates indicate a sharp decay in influenza transmission with the distance between infectious and susceptible cities, consistent with spread dominated by work commutes rather than air traffic. Two early-onset seasons associated with antigenic novelty had particularly localized modes of spread, suggesting that novel strains may spread in a more localized fashion than previously anticipated.
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