期刊
PHYSICAL REVIEW X
卷 7, 期 1, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevX.7.011031
关键词
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资金
- NVIDIA Corporation
- National Science Foundation [1401432]
- National Institutes of Health [R01GM109888]
- Direct For Biological Sciences
- Div Of Biological Infrastructure [1460507] Funding Source: National Science Foundation
- Division Of Physics
- Direct For Mathematical & Physical Scien [1401432] Funding Source: National Science Foundation
A broad range of membrane proteins display anomalous diffusion on the cell surface. Different methods provide evidence for obstructed subdiffusion and diffusion on a fractal space, but the underlying structure inducing anomalous diffusion has never been visualized because of experimental challenges. We addressed this problem by imaging the cortical actin at high resolution while simultaneously tracking individual membrane proteins in live mammalian cells. Our data confirm that actin introduces barriers leading to compartmentalization of the plasma membrane and that membrane proteins are transiently confined within actin fences. Furthermore, superresolution imaging shows that the cortical actin is organized into a self-similar meshwork. These results present a hierarchical nanoscale picture of the plasma membrane.
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