期刊
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
卷 139, 期 -, 页码 31-38出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cmpb.2016.10.021
关键词
Brain tumor; Diffuse glioma; Glioblastoma; Computer-aided diagnosis; Image moment; Magnetic resonance imaging
类别
资金
- Ministry of Science and Technology in Taiwan [MOST 104-2218-E-038-004, MOST 1032314-B-038-067]
- Taipei Medical University [TMU 104-AE1B04]
Background and objectives: A computer-aided diagnosis (CAD) system based on quantitative magnetic resonance imaging (MRI) features was developed to evaluate the malignancy of diffuse gliomas, which are central nervous system tumors. Methods: The acquired image database for the CAD performance evaluation was composed of 34 glioblastomas and 73 diffuse lower-grade gliomas. In each case, tissues enclosed in a delineated tumor area were analyzed according to their gray-scale intensities on MRI scans. Four histogram moment features describing the global gray-scale distributions of gliomas tissues and 14 textural features were used to interpret local correlations between adjacent pixel values. With a logistic regression model, the individual feature set and a combination of both feature sets were used to establish the malignancy prediction model. Results: Performances of the CAD system using global, local, and the combination of both image feature sets achieved accuracies of 76%, 83%, and 88%, respectively. Compared to global features, the combined features had significantly better accuracy (p = 0.0213). With respect to the pathology results, the CAD classification obtained substantial agreement kappa = 0.698, p < 0.001. Conclusions: Numerous proposed image features were significant in distinguishing glioblastomas from lower-grade gliomas. Combining them further into a malignancy prediction model would be promising in providing diagnostic suggestions for clinical use. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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