期刊
CIRCULATION RESEARCH
卷 120, 期 6, 页码 941-959出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.116.309040
关键词
cardiac development; cardiac regeneration; cardiomyocyte maturation; signaling pathways; transcriptional regulation
资金
- National Institutes of Health (NIH) [HL098166, HL116461]
- NIH Office of Director's Pioneer Award [LM012179]
- NIH/NHLBI [U01 0099776]
- Cardiovascular Institute
- Division of Cardiology, Department of Medicine
- Institute for Stem Cell Biology and Regenerative Medicine
- Child Health Research Institute/Lucile Packard Foundation for Children at Stanford
- Department of Pediatrics at Stanford
- Stanford Medical Scientist Training Program NIH [T32 GM007365]
- [F32HL13423501]
- [T32HL07572]
Palliative surgery for congenital heart disease has allowed patients with previously lethal heart malformations to survive and, in most cases, to thrive. However, these procedures often place pressure and volume loads on the heart, and over time, these chronic loads can cause heart failure. Current therapeutic options for initial surgery and chronic heart failure that results from failed palliation are limited, in part, by the mammalian heart's low inherent capacity to form new cardiomyocytes. Surmounting the heart regeneration barrier would transform the treatment of congenital, as well as acquired, heart disease and likewise would enable development of personalized, in vitro cardiac disease models. Although these remain distant goals, studies of heart development are illuminating the path forward and suggest unique opportunities for heart regeneration, particularly in fetal and neonatal periods. Here, we review major lessons from heart development that inform current and future studies directed at enhancing cardiac regeneration.
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