期刊
BIOMACROMOLECULES
卷 18, 期 2, 页码 475-482出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.6b01553
关键词
-
资金
- National Institutes of Health [R01DE020843]
- NSF [DMR 1501324]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1501324] Funding Source: National Science Foundation
The synthesis of a sulfoxide-based water-soluble polymer, poly(2-(methylsulfinyl)ethyl acrylate) (polyMSEA), a polymeric analogue of DMSO, by atom transfer radical polymerization (ATRP) is reported. Well-defined linear polymers were synthesized using relatively low amounts of copper catalyst (1000 or 100 ppm). Two types of star polymers were synthesized by either an arm-first approach or a core-first approach using a biodegradable beta-cyclodextrin core. The glass transition temperatures of both the linear polymer (16 degrees C) and star polymer (32 degrees C) were determined by differential scanning calorimetry (DSC). The lower critical solution temperature (LCST) of poly(MSEA) was estimated to be ca. 140 degrees C by extrapolating the LCST of a series of copolymers with NIPAM. Cytotoxicity tests revealed that both the linear and star polymers have low toxicity, even at concentrations up to 3 mg/mL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据