期刊
MATERIALS
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ma10020191
关键词
titanium; chondroitin sulphate; cartilage tissue; aldehyde; adhesion
类别
资金
- Natural Science Foundation of Guangdong Province [2015A030313493, 2016A030308014]
- National Natural Science Foundation of China [51541201, 51372087]
- Science and Technology Planning Project of Guangdong Province [2014A010105048]
- National High Technology Research and Development Program of China [2015AA033502]
Integration and stability of hydrogels and surrounding cartilage/bone tissue is crucial for both immediate functionality and long-term performance of the tissue. In this work, chondroitin sulphate (CS) a polysaccharide found in cartilage and other tissues was used to synthesize a tough hydrogel that was chemically functionalized with methacrylate and aldehyde groups, bonding to surrounding tissue via a dual-bonded approach. The hydrogel can not only chemically anchor onto implanted titanium at the subchondral bone, but also on cartilage tissue via the Schiff-base reaction. In vitro experiments confirmed that the strategy improved hydrogel implant stability with cartilage tissue, was favorable for chondrocyte attachment, and has the potential to quickly and effectively repair cartilage defects and maintain joint functionality for a long time.
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