Isolation of Lupeol, Design and Synthesis of Lupeol Derivatives and their Biological Activity

The triterpenoid, lupeol (1) has been isolated from the leaves extract of Walsura trifoliate. Few novel derivatives (4a-j) were synthesized from the naturally occurring lupeol (1) and confirmed by spectroscopic methods, and tested for antimicrobial and anti-proliferative activity against MDAMB-231, IMR32and A549 cell lines. This all compound showed moderate activities.