期刊
OPEN BIOLOGY
卷 7, 期 11, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.170204
关键词
APC/C; cell cycle; spindle assembly checkpoint; cryo-EM
资金
- MRC [MC_UP_1201/6]
- Cancer Research UK [C576/A14109]
- Gates Cambridge Scholarship
- Boehringer Ingelheim Fonds
- Cancer Research UK [14109, 24307] Funding Source: researchfish
- Medical Research Council [MC_UP_1201/6] Funding Source: researchfish
- MRC [MC_UP_1201/6] Funding Source: UKRI
The anaphase promoting complex or cyclosome (APC/C) is a large multisubunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators. During the two decades since its discovery, much has been learnt concerning its role in recognizing and ubiquitinating specific proteins in a cell-cycle-dependent manner, the mechanisms governing substrate specificity, the catalytic process of assembling polyubiquitin chains on its target proteins, and its regulation by phosphorylation and the spindle assembly checkpoint. The past few years have witnessed significant progress in understanding the quantitative mechanisms underlying these varied APC/C functions. This review integrates the overall functions and properties of the APC/C with mechanistic insights gained from recent cryo-electron microscopy (cryo-EM) studies of reconstituted human APC/C complexes.
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