期刊
OPEN BIOLOGY
卷 7, 期 11, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.170139
关键词
Foxj1a; Shh; ependymal radial glia; CSF-contacting neurons; spinal cord injury; zebrafish
资金
- FCT (Portugal) [PTDC/BIM-MED/1375/2012, PTDC/BIM-MED/3295/2014, SFRH/BPD/100162/2014]
- FCT (Portugal)
- EMBO [605-2012]
- Fundação para a Ciência e a Tecnologia [PTDC/BIM-MED/1375/2012] Funding Source: FCT
Zebrafish are able to regenerate the spinal cord and recovermotor and sensory functions upon severe injury, through the activation of cells located at the ependymal canal. Here, we show that cells surrounding the ependymal canal in the adult zebrafish spinal cord express Foxj1a. We demonstrate that ependymal cells express Foxj1a from their birth in the embryonic neural tube and that Foxj1a activity is required for the final positioning of the ependymal canal. We also show that in response to spinal cord injury, Foxj1a ependymal cells actively proliferate and contribute to the restoration of the spinal cord structure. Finally, this study reveals that Foxj1a expression in the injured spinal cord is regulated by regulatory elements activated during regeneration. These data establish Foxj1a as a pan-ependymal marker in development, homeostasis and regeneration and may help identify the signals that enable this progenitor population to replace lost cells after spinal cord injury.
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