期刊
OPEN BIOLOGY
卷 7, 期 10, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.170167
关键词
SUMOylation; SUMO pathway; deSUMOylation; disease
资金
- National Key Basic Research Program of China [2013CB911303, 2011CB910703]
- National Natural Science Foundation of China [31470810, 31071235]
- Science and Technology Department of Sichuan Province [2017JY0232]
- Health and Family Planning Commission of Sichuan Province [17ZD045]
SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis. The imbalance of SUMOylation and deSUMOylation has been associated with the occurrence and progression of various diseases. Herein, we summarize and discuss the signal crosstalk between SUMOylation and ubiquitination of proteins, protein SUMOylation relations with several diseases, and the identification approaches for SUMOylation site. With the continuous development of bioinformatics and mass spectrometry, several accurate and high-throughput methods have been implemented to explore small ubiquitin-likemodifier-modified substrates and sites, which is helpful for deciphering protein SUMOylation-mediated molecular mechanisms of disease.
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