期刊
OPEN BIOLOGY
卷 7, 期 8, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.170140
关键词
Wnt signalling; stem cell niche; tissue engineering; protein immobilization; cell therapy and regenerative medicine; adult and embryonic stem cells
资金
- Sir Henry Dale Fellowship [102513/Z/13/Z]
- UK Regenerative Medicine Platform (MRC Niche Hub Reference) [MR/K026666/1]
- Wellcome Trust [102513/Z/13/Z] Funding Source: Wellcome Trust
- MRC [MR/K026666/1] Funding Source: UKRI
- Medical Research Council [MR/K026666/1] Funding Source: researchfish
Stem cells reside in niches where spatially restricted signals maintain a delicate balance between stem cell self-renewal and differentiation. Wnt family proteins are particularly suited for this role as they are modified by lipids, which constrain and spatially regulate their signalling range. In recent years, Wnt/beta-catenin signalling has been shown to be essential for the self-renewal of a variety of mammalian stem cells. In this review, we discuss Wnt-responsive stem cells in their niche, and mechanisms by which Wnt ligands are presented to responsive cells. We also highlight recent progress in molecular visualization that has allowed for the monitoring of Wnt signalling within the stem cell compartment and new approaches to recapitulate this niche signalling in vitro. Indeed, new technologies that present Wnt in a localized manner and mimic the three-dimensional microenvironment of stem cells will advance our understanding of Wnt signalling in the stem cell niche. These advances will expand current horizons to exploit Wnt ligands in the rapidly evolving fields of tissue engineering and regenerative medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据