期刊
MRS COMMUNICATIONS
卷 7, 期 3, 页码 289-308出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1557/mrc.2017.91
关键词
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资金
- National Center for Advancing Translational Sciences (NCATS) of the Clinical and Translational Science Center at Weill Cornell Medical College [TL1TR000459]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health (NIH) [F31AR070009]
Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues. This prospective review discusses methodologies for tissue engineering the enthesis, outlined in three key design inputs: materials processing methods, cellular contributions, and biochemical factors.
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