期刊
MOLECULAR BRAIN
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13041-017-0306-y
关键词
Serotonin; Depression; Antidepressant; Dentate gyrus; 5-HT1A receptor; Hippocampus; Adult neurogenesis
资金
- NIH [R01 MH112861]
- Brain & Behavior Research Foundation
Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review, we will discuss the evidence that links serotonin and serotonin receptors to the etiology of depression and the mechanisms underlying response to antidepressant treatment. We will then revisit the role of serotonin in three distinct hypotheses that have been proposed over the last several decades to explain the pathophysiology of depression: the monoamine, neurotrophic, and neurogenic hypotheses. Finally, we will discuss how recent studies into serotonin receptors have implicated specific neural circuitry in mediating the antidepressant response, with a focus being placed on the hippocampus.
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