期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 14, 页码 3956-3960出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201612463
关键词
hypervalent compounds; iodine; oxidation; phenol; silicon
资金
- JSPS.KAKENHI [15H05755, 15H05484, 24245020]
- Program for Leading Graduate Schools: IGER Program in Green Natural Sciences (MEXT)
- JSPS Research Fellowship for Young Scientists
- Grants-in-Aid for Scientific Research [15H05484, 14J10428] Funding Source: KAKEN
A site-selective hydroxylative dearomatization of 2-substituted phenols to either 1,2-benzoquinols or their cyclodimers, catalyzed by 4,5-dimethyl-2-iodoxybenzenesulfonic acid with Oxone, has been developed. Natural products such as biscarvacrol and lacinileneC methyl ether could be synthesized efficiently under mild reaction conditions. Furthermore, both the reaction rate and site selectivity could be further improved by the introduction of a trialkylsilylmethyl substituent at the 2-position of phenols. The corresponding 1,2-quinols could be transformed into various useful structural motifs by [4+2] cycloaddition cascade reactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据