期刊
BLOOD
卷 129, 期 14, 页码 1991-2001出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2016-10-744441
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资金
- Swedish Medical Council (Vetenskapsradet)
- Foundation Blanceflor Boncompagni-Ludovisi
- Swedish Society of Medicine
- Fernstrom Foundation
- China Scholarship Council
- Karolinska Institutet
- COST
Neutrophils are critical cells of the innate immune system and rapidly respond to tissue injury and infection. Increasing evidence also indicates that neutrophils have versatile functions in contributing to adaptive immunity by internalizing and transporting antigen and influencing antigen-specific responses. Here, we demonstrate that freshly isolated human neutrophils can function as antigen-presenting cells (APCs) to memory CD4(+) T cells. Neutrophils pulsed with the cognate antigens cytomegalovirus pp65 or influenza hemagglutinin were able to present the antigens to autologous antigen-specific CD4(+) T cells in a major histocompatibility complex class II (MHC-II; HLA-DR)-dependent manner. Although myeloid dendritic cells and monocytes showed superior presenting ability, neutrophils consistently displayed antigen presentation capability. Upregulation of HLA-DR on neutrophils required the presence of the antigen-specific or activated T cells whereas exposure to innate stimuli such as Toll-like receptor ligands was not sufficient. Neutrophils sorted from vaccine-draining lymph nodes from rhesus macaques also showed expression of HLA-DRand were capable of presenting vaccine antigen to autologous antigen-specificmemory CD4(+) T cells ex vivo. Altogether, the data demonstrate that neutrophils can adapt a function as APCs and, in combination with their abundance in the immune system, may have a significant role in regulating antigen-specific T-cell responses.
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